(2Z,3Z) -U0126
U0126 is a potent and selective noncompetitive inhibitor of MEK1 and MEK2 (IC50: 72 nM and 58 nM, respectively), blocking the MAPK/ERK pathway. It suppresses AP-1 activity and has been used in vitro to inhibit the anchorage-independent growth of ras-transformed cells and in vivo to study cancer and neurological disease models.
Product Specifications
CAS Number
218601-62-8
Field of Research
Signal Transduction
Smiles
C (/C (=C (/SC1=C (N) C=CC=C1) \N) /C#N) (=C (\SC2=C (N) C=CC=C2) /N) \C#N
Molecular Formula
C18H16N6S2
Molecular Weight
380.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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