Tivumecirnon
Tivumecirnon (FLX475) is an orally bioavailable, selective CCR4 antagonist that blocks regulatory T cell (Treg) migration into tumors. This mechanism has demonstrated antitumor activity in preclinical models, supporting its research use in oncology for modulating the tumor microenvironment.
Product Specifications
CAS Number
2174938-78-2
Product Name Alternative
FLX 475, FLX475, FLX-475, Tivumecirnon
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
99.88% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (6.07 mM) ; DMSO:80 mg/mL (147.22 mM)
Smiles
[C@H] (C) (N1C=2C (C (C (F) (F) F) =N1) =NC=C (N2) N3CC (C3) [C@@H]4CN (CCO) CCC4) C5=C (Cl) C=C (Cl) C=C5
Molecular Formula
C24H27Cl2F3N6O
Molecular Weight
543.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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