SB02024
SB02024 is a VPS34 inhibitor that blocks autophagy, activates cGAS-STING signaling, and sensitizes tumors to STING agonists. It demonstrates efficacy in reducing breast cancer xenograft growth and, in vitro, significantly enhances the cytotoxicity of Sunitinib and Erlotinib in monolayer and spheroid models of MDA-MB-231 and MCF-7 cells.
Product Specifications
CAS Number
2126737-28-6
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
[C@] (F) (F) (F) [C@@H]1N (CCCC1) C2=CC (=CC (=O) N2) N3[C@H] (C) COCC3
Molecular Formula
C16H22F3N3O2
Molecular Weight
345.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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