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JPI-547 HCl

JPI-547 (NOV 1402) is an orally active dual PARP1/2 and Tankyrase1/2 inhibitor. It exhibits single-agent anti-tumor efficacy in BRCA-deficient models and shows synergistic activity in combination with chemotherapy or immune checkpoint inhibitors in preclinical in vivo studies.

Product Specifications

CAS Number

2055357-65-6

Smiles

Cl.Cl.O=c1[nH]c2cc (CN3CCN (CC3) c3ccc (cn3) C#N) ccc2c2NCCCc12

Molecular Formula

C23H26Cl2N6O

Molecular Weight

473.402

Storage Conditions

-20°C

Notes

For research use only.

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