DHA-paclitaxel
DHA-paclitaxel (Taxoprexin) is a prodrug that conjugates paclitaxel to the fatty acid DHA for targeted tumor delivery. It inhibits microtubule disassembly and Bcl-2 function, blocking cell division and inducing apoptosis. This agent shows enhanced pharmacokinetics and antitumor efficacy in preclinical in vivo cancer models.
Product Specifications
CAS Number
199796-52-6
Field of Research
Pharmacology & Drug Discovery
Smiles
O (C (C) =O) [C@]12[C@]3 ([C@H] (OC (=O) C4=CC=CC=C4) [C@@]5 (O) C (C) (C) C ([C@@H] (OC (C) =O) C (=O) [C@]3 (C) [C@@H] (O) C[C@]1 (OC2) [H]) =C (C) [C@@H] (OC ([C@@H] ([C@@H] (NC (=O) C6=CC=CC=C6) C7=CC=CC=C7) OC (CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC) =O) =O) C5) [H]
Molecular Formula
C69H81NO15
Molecular Weight
1164.38
Storage Conditions
-20°C
Notes
For research use only.
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