Pamiparib hydrate

Pamiparib (BGB-290) is a potent and selective PARP inhibitor that disrupts DNA repair via the base-excision repair pathway, leading to genomic instability and apoptosis. It is widely used in cancer research to study synthetic lethality in BRCA-deficient models and to potentiate the effects of DNA-damaging agents in both in vitro and in vivo experiments.