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L-778123 Dihydrochloride

L-778123 is a dual inhibitor of farnesyltransferase (FPTase) and geranylgeranyltransferase-I (GGPTase-I), effectively blocking Ki-Ras prenylation. It has demonstrated radiosensitizing properties in patient-derived pancreatic cancer cell lines and, combined with radiotherapy, showed acceptable toxicity in clinical trials for locally advanced pancreatic cancer.

Product Specifications

CAS Number

183499-56-1

Field of Research

Metabolism Research

Smiles

Cl.Cl.Clc1cccc (c1) N1CCN (Cc2cncn2Cc2ccc (cc2) C#N) CC1=O

Molecular Formula

C22H22Cl3N5O

Molecular Weight

478.802

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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