L-778123 Dihydrochloride
L-778123 is a dual inhibitor of farnesyltransferase (FPTase) and geranylgeranyltransferase-I (GGPTase-I), effectively blocking Ki-Ras prenylation. It has demonstrated radiosensitizing properties in patient-derived pancreatic cancer cell lines and, combined with radiotherapy, showed acceptable toxicity in clinical trials for locally advanced pancreatic cancer.
Product Specifications
CAS Number
183499-56-1
Field of Research
Metabolism Research
Smiles
Cl.Cl.Clc1cccc (c1) N1CCN (Cc2cncn2Cc2ccc (cc2) C#N) CC1=O
Molecular Formula
C22H22Cl3N5O
Molecular Weight
478.802
Storage Conditions
-20°C
Notes
For research use only.
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