CI-898 HCl
CI-898 HCl is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor, with binding enhanced by NADPH. It arrests the cell cycle at G1/S in L1210 leukemia cells, overcomes methotrexate resistance, and demonstrates synergistic activity with agents like doxorubicin in advanced P338 leukemia mouse models.
Product Specifications
CAS Number
1658520-97-8
Field of Research
Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology
Smiles
Cl.Cl.Cl.COc1cc (NCc2ccc3nc (N) nc (N) c3c2C) cc (OC) c1OC
Molecular Formula
C19H26Cl3N5O3
Molecular Weight
478.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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