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CI-898 HCl

CI-898 HCl is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor, with binding enhanced by NADPH. It arrests the cell cycle at G1/S in L1210 leukemia cells, overcomes methotrexate resistance, and demonstrates synergistic activity with agents like doxorubicin in advanced P338 leukemia mouse models.

Product Specifications

CAS Number

1658520-97-8

Field of Research

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Smiles

Cl.Cl.Cl.COc1cc (NCc2ccc3nc (N) nc (N) c3c2C) cc (OC) c1OC

Molecular Formula

C19H26Cl3N5O3

Molecular Weight

478.8

Storage Conditions

-20°C

Notes

For research use only.

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