PH11
PH11 is a novel small molecule inhibitor of Focal Adhesion Kinase (FAK) . It overcomes TRAIL resistance in cancer cells, such as PANC-1 pancreatic carcinoma, by suppressing FAK and the PI3K/AKT pathways to downregulate c-FLIP and restore apoptosis. This mechanism supports its investigation in both in vitro and in vivo oncology research models.
Product Specifications
CAS Number
1627843-95-1
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
N (C=1N2C (N=C (NC3=C (C (OC) =O) C=CC=C3) N1) =NC=C2) C4=CC (OC) =C (OC) C (OC) =C4
Molecular Formula
C22H22N6O5
Molecular Weight
450.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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