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VUF14480

VUF14480 is a covalent partial agonist that selectively and irreversibly binds to cysteine 98 (Cys3.36) of the human histamine H4 receptor. It demonstrates submicromolar affinity and partial agonism in both G protein signaling and β-arrestin2 recruitment assays, making it a valuable tool compound for investigating H4R pharmacology in vitro.

Product Specifications

CAS Number

1605304-31-1

Smiles

C (=C) C=1N=C (C=C (N1) C2=CC=CC=C2) N3CCN (C) CC3

Molecular Formula

C17H20N4

Molecular Weight

280.37

Storage Conditions

-20°C

Notes

For research use only.

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