Abivertinib HCl
Abivertinib (AC0010) is a third-generation EGFR and BTK inhibitor with demonstrated efficacy in research models of acute myeloid leukemia (AML), particularly against FLT3-ITD mutant cells. It shows superior sensitivity compared to ibrutinib in vitro, inducing apoptosis and cell cycle arrest, and holds promise for combination therapies in oncology research.
Product Specifications
CAS Number
1557268-90-2
Smiles
Cl.Cl.CN1CCN (CC1) c1ccc (Nc2nc (Oc3cccc (NC (=O) C=C) c3) c3cc[nH]c3n2) cc1F
Molecular Formula
C26H28Cl2FN7O2
Molecular Weight
560.4554
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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