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Abivertinib HCl

Abivertinib (AC0010) is a third-generation EGFR and BTK inhibitor with demonstrated efficacy in research models of acute myeloid leukemia (AML), particularly against FLT3-ITD mutant cells. It shows superior sensitivity compared to ibrutinib in vitro, inducing apoptosis and cell cycle arrest, and holds promise for combination therapies in oncology research.

Product Specifications

CAS Number

1557268-90-2

Smiles

Cl.Cl.CN1CCN (CC1) c1ccc (Nc2nc (Oc3cccc (NC (=O) C=C) c3) c3cc[nH]c3n2) cc1F

Molecular Formula

C26H28Cl2FN7O2

Molecular Weight

560.4554

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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