KRC-108
KRC-108 is a multi-kinase inhibitor targeting Ron, Flt3, TrkA, and c-Met, with enhanced activity against oncogenic c-Met mutants. It demonstrates potent anti-proliferative effects in vitro (GI50 0.01-4.22 μM) and inhibits tumor growth in HT29 and NCI-H441 xenograft models, supporting its role as a lead compound in oncology research.
Product Specifications
CAS Number
1146944-35-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
NC1=C (C2=NC=3C (O2) =CC=CC3) C=C (C=N1) C4=CN (N=C4) C5CCNCC5
Molecular Formula
C20H20N6O
Molecular Weight
360.41
Storage Conditions
-20°C
Notes
For research use only.
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