Plogosertib
Plogosertib (CYC140) is a potent, selective, and orally bioavailable ATP-competitive inhibitor of PLK1 (IC50=3 nM) . It demonstrates robust antiproliferative effects in vitro and has shown promising antitumor activity in vivo, supporting its research use in both solid and hematological cancer models.
Product Specifications
CAS Number
1137212-79-3
Product Name Alternative
CYC 140, CYC140, CYC-140, AC 220, AC 010220, AC-220, AC010220, AC-010220, AC010220.2HCl, PLK1, Plogosertib, Quizartinib, Quizartinib dihydrochloride, Quizartinib HCl
Field of Research
Cell Biology
Purity
99.22% (May vary between batches)
Smiles
O=C1C2 (CN (C=3C (N1C) =CN=C (NC4=C (OC) C=C (C (N[C@@H]5CC[C@H] (CC5) N6CCN (C) CC6) =O) C=C4) N3) C7CCCC7) CC2
Molecular Formula
C34H48N8O3
Molecular Weight
616.797
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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