Acamprosate (calcium)

Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.

Product Specifications

CAS Number

[77337-73-6]

Product Name Alternative

Calcium N-acetylhomotaurinate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor; iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Acamprosate-calcium.html

Purity

98.30

Solubility

DMSO : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

CC(NCCCS([O-])(=O)=O)=O.[0.5Ca2+]

Molecular Formula

C5H10NO4S.1/2Ca

Molecular Weight

200.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.) . Alcohol Clin Exp Res. 2012 Jun;36 (6) :967-9. doi: 10.1111/j.1530-0277.2012.01827.x.|[2]Witkiewitz K, Saville K, Hamreus K. Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility. Ther Clin Risk Manag. 2012;8:45-53.|[3]Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15.|[4]Palucha-Poniewiera A, Pilc A. Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39 (1) :102-6.|[5]Hinton DJ, et al.  Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1. Neuropharmacology. 2012 Jun;62 (8) :2480-8.|[6]Pradhan G, et al., Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice. Psychopharmacology (Berl) . 2018 Jul;235 (7) :2027-2040.|[7]Allgaier C, et al., Acamprosate inhibits Ca2+ influx mediated by NMDA receptors and voltage-sensitive Ca2+ channels in cultured rat mesencephalic neurones. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362 (4-5) :440-3.