WRR-483
WRR-483 is a vinyl sulfone-based cysteine protease inhibitor active against cruzain, demonstrating potent trypanocidal efficacy in both cell culture and an acute Chagas disease mouse model. This compound covalently targets the protease's active site, showing pH-dependent activity and positioning it as a promising research tool for developing anti-parasitic therapies.
Product Specifications
CAS Number
1076088-50-0
Field of Research
Infectious Disease & Virology
Smiles
[C@@H] (NC (=O) N1CCN (C) CC1) (C (N[C@H] (C=CS (=O) (=O) C2=CC=CC=C2) CCC3=CC=CC=C3) =O) CCCNC (=N) N
Molecular Formula
C29H41N7O4S
Molecular Weight
583.75
Storage Conditions
-20°C
Notes
For research use only.
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