KAL-21404358
KAL-21404358 is a novel allosteric inhibitor targeting the P110 site of K-RasG12D. This binding disrupts the K-RasG12D/B-Raf interaction, thereby inhibiting downstream RAF-MEK-ERK and PI3K-AKT signaling pathways. It is a valuable research tool for investigating Ras-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
1065573-84-3
Field of Research
Pharmacology & Drug Discovery
Smiles
OC=1C2=C (N=C (CN3CC (CCO) N (CC (C) (C) C) CC3) C1) C=CC=C2
Molecular Formula
C21H31N3O2
Molecular Weight
357.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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