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APTO-253 isomer

APTO-253 isomer is a 6-fluoro-substituted analog of the MTF-1 inhibitor APTO-253 (LOR-253) . It functions by inhibiting MTF-1 to induce KLF4 expression, leading to cell cycle arrest via cyclin D1 downregulation. This compound is used in cancer research, with studies demonstrating its activity in both cellular and animal models of leukemia and solid tumors.

Product Specifications

CAS Number

1422826-80-9

Smiles

CC1=C (C=2NC=3C (=C4C (=C5C3C=CC=N5) N=CC=C4) N2) C=6C (N1) =CC (F) =CC6

Molecular Formula

C22H14FN5

Molecular Weight

367.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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