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CR-6086

CR6086 is a potent and selective EP4 receptor antagonist with a Ki of 16.6 nM, effectively blocking PGE2-induced cAMP signaling. It demonstrates immunomodulatory and anti-inflammatory properties distinct from COX inhibitors, showing disease-modifying antirheumatic drug (DMARD) effects in rodent models of immune-mediated inflammatory diseases.

Product Specifications

CAS Number

1417742-86-9

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Smiles

N (C (=O) C1N (CC2=CC=C (C (F) (F) F) C=C2) CCC3 (C1) CC3) C4 (CC4) C5=CC=C (C (O) =O) C=C5

Molecular Formula

C26H27F3N2O3

Molecular Weight

472.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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