CR-6086
CR6086 is a potent and selective EP4 receptor antagonist with a Ki of 16.6 nM, effectively blocking PGE2-induced cAMP signaling. It demonstrates immunomodulatory and anti-inflammatory properties distinct from COX inhibitors, showing disease-modifying antirheumatic drug (DMARD) effects in rodent models of immune-mediated inflammatory diseases.
Product Specifications
CAS Number
1417742-86-9
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
N (C (=O) C1N (CC2=CC=C (C (F) (F) F) C=C2) CCC3 (C1) CC3) C4 (CC4) C5=CC=C (C (O) =O) C=C5
Molecular Formula
C26H27F3N2O3
Molecular Weight
472.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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