RO2443
RO2443 is a small molecule that disrupts the p53-MDM2/MDMX interactions by inducing dimerization of these negative regulators, thereby reactivating the p53 tumor suppressor pathway. It serves as a valuable chemical probe for studying p53 biology in cancer research and has demonstrated activity in both cellular assays and in vivo tumor models.
Product Specifications
CAS Number
1416663-79-0
Smiles
C (C=1C=2C (=C (C) C (Cl) =CC2) NC1) =C3C (=O) N (CC4=CC (F) =C (F) C=C4) C (=O) N3
Molecular Formula
C20H14ClF2N3O2
Molecular Weight
401.79
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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