FGF/PDGF/VEGF RTK Inhibitor
This small molecule is a potent, ATP-competitive inhibitor targeting PDGFRβ, FGFR1, and VEGFR2 with respective IC50 values of 20, 90, and 240 nM. It reversibly inhibits VEGF-driven proliferation in HMVECs (EC50 = 420 nM) and is a valuable tool for studying angiogenesis and tumor growth in both cellular and animal models.
Product Specifications
CAS Number
144335-37-5
Field of Research
Cardiovascular Research; Stem Cell & Developmental Biology; Pharmacology & Drug Discovery
Smiles
OC1=C (C (=O) NC=2C1=CC=CC2) C=3NC=4C (N3) =CC=CC4
Molecular Formula
C16H11N3O2
Molecular Weight
277.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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