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FGF/PDGF/VEGF RTK Inhibitor

This small molecule is a potent, ATP-competitive inhibitor targeting PDGFRβ, FGFR1, and VEGFR2 with respective IC50 values of 20, 90, and 240 nM. It reversibly inhibits VEGF-driven proliferation in HMVECs (EC50 = 420 nM) and is a valuable tool for studying angiogenesis and tumor growth in both cellular and animal models.

Product Specifications

CAS Number

144335-37-5

Field of Research

Cardiovascular Research; Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Smiles

OC1=C (C (=O) NC=2C1=CC=CC2) C=3NC=4C (N3) =CC=CC4

Molecular Formula

C16H11N3O2

Molecular Weight

277.28

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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