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SGK1 inhibitor

This small molecule selectively inhibits serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2 over SGK3. It demonstrates functional activity by blocking GSK3β phosphorylation in vitro and, in combination with PI3Kα inhibitor BYL719, reduces viability of resistant cancer cells and suppresses tumor growth in xenograft models.

Product Specifications

CAS Number

1426214-51-8

Field of Research

Metabolism Research, Pharmacology & Drug Discovery; Cell Biology

Smiles

N (S (=O) (=O) C1=C (Cl) C (Cl) =CC=C1) C2=CC=C (C=3N=C4C (=NC3) C (N) =NN4) C=C2

Molecular Formula

C17H12Cl2N6O2S

Molecular Weight

435.29

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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