11β-HSD1 inibitor 19

This potent small molecule inhibitor, designated as compound 19, demonstrates high inhibitory activity against both human and mouse 11β-HSD1 enzymes, with IC50 values of 16 nM and 10 nM, respectively. It is a valuable research tool for investigating glucocorticoid metabolism in metabolic and inflammatory disease models, both in vitro and in vivo.