Pan-KRAS degrader 1
Pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant Ki value of 25 nM for KRASG12V .pan-KRAS degrader 1 has antitumor activity[1].
Product Specifications
CAS Number
[2937327-83-6]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-degrader-1.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(S1)=C(C#N)C2=C1CCC[C@@]2(C3=NC(C4=NC(N5[C@@H](C)CNCCC5)=NC=C4)=NO3)C
Molecular Formula
C22H26N8OS
Molecular Weight
450.56
References & Citations
[1]Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385 (6715) :1338-1347.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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