4-methoxylonchocarpin
4-Methoxylonchocarpin is a natural compound isolated from Abrus precatorius roots, demonstrating potent anti-inflammatory activity. It functions by inhibiting LPS binding to TLR4 in macrophages, thereby suppressing NF-κB-mediated TNF-α expression, and has shown efficacy in a murine TNBS-induced colitis model. This makes it a valuable small molecule for researching TLR4/NF-κB signaling in inflammatory diseases.
Product Specifications
CAS Number
51589-67-4
Product Name Alternative
NF-kB, NFkB, NF-κB, NFκB, TNF
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Purity
98.00% (May vary between batches)
Smiles
OC1=C2C (OC (C) (C) C=C2) =CC=C1C (/C=C/C3=CC=C (OC) C=C3) =O
Molecular Formula
C21H20O4
Molecular Weight
336.38
Storage Conditions
Store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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