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PPK-188

PPK-188 (CFT) is a potent and selective covalent inhibitor of tryparedoxin (Tpx), a key enzyme in the trypanothione-based antioxidant defense of African trypanosomes. It demonstrates potent trypanocidal activity in vitro and has shown efficacy in reducing parasite burden in animal models of African trypanosomiasis, supporting its use in antiparasitic research.

Product Specifications

CAS Number

852400-39-6

Smiles

FC1=CC=C (C=C1) C1=CSC2=C1C (=O) N=C (CCl) N2

Molecular Formula

C13H8ClFN2OS

Molecular Weight

294.73

Storage Conditions

-20°C

Notes

For research use only.

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