GTP-14564
GTP-14564 is a novel tyrosine kinase inhibitor targeting both wild-type and ITD-mutant FLT3. It demonstrates potent activity against FLT3-ITD-driven cell proliferation in vitro, requiring significantly higher concentrations to inhibit ligand-dependent wild-type FLT3 growth. This selectivity makes it a valuable research tool for studying FLT3 signaling in hematological malignancies.
Product Specifications
CAS Number
34823-86-4
Product Name Alternative
Tyrosine Kinases, TyrosineKinases, FLT3 (ITD), FLT3 (WT), GTP14564, GTP-14564, GTP 14564
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.69% (May vary between batches)
Solubility
DMF:27 mg/mL (115.26 mM) ; DMSO:60 mg/mL (256.14 mM)
Smiles
C12=C (C=3C (O1) =CC=CC3) NN=C2C4=CC=CC=C4
Molecular Formula
C15H10N2O
Molecular Weight
234.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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