APKC-I

APKC-I is a highly specific small molecule inhibitor of atypical PKC isoforms ζ and ι. It effectively blocks VEGF-induced endothelial hyperpermeability in both cellular assays and animal models, thereby mitigating vascular leakage in conditions such as ischemia-reperfusion injury. This tool compound is valuable for research in vascular biology, angiogenesis, and inflammatory disease models.