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ARN 14494

ARN 14494 is a potent SPT inhibitor (IC50 = 27.3 nM) that blocks ceramide synthesis. It demonstrates neuroprotective effects in vitro by reducing amyloid-beta-induced toxicity, inflammation, and oxidative stress in neuronal and astrocyte co-culture models relevant to Alzheimer's disease research.

Product Specifications

CAS Number

1037837-27-6

Field of Research

Cell Biology, Immunology & Inflammation, Neuroscience

Smiles

O=C1N (C=2C (C1) =CC (C (NC) =O) =CC2) C3CCN (CC (=O) N4CC5C (C4) CCC5) CC3

Molecular Formula

C24H32N4O3

Molecular Weight

424.54

Storage Conditions

-20°C

Notes

For research use only.

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