ARN 14494
ARN 14494 is a potent SPT inhibitor (IC50 = 27.3 nM) that blocks ceramide synthesis. It demonstrates neuroprotective effects in vitro by reducing amyloid-beta-induced toxicity, inflammation, and oxidative stress in neuronal and astrocyte co-culture models relevant to Alzheimer's disease research.
Product Specifications
CAS Number
1037837-27-6
Field of Research
Cell Biology, Immunology & Inflammation, Neuroscience
Smiles
O=C1N (C=2C (C1) =CC (C (NC) =O) =CC2) C3CCN (CC (=O) N4CC5C (C4) CCC5) CC3
Molecular Formula
C24H32N4O3
Molecular Weight
424.54
Storage Conditions
-20°C
Notes
For research use only.
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