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GSK1370319A

GSK1370319A is a potent and selective P2X7 receptor antagonist (IC50 = 3.2 nM) that blocks NLRP3 inflammasome assembly and IL-1β release in glial cells. It is a valuable research tool for studying neuroinflammation, demonstrating protective effects against neuronal loss in vitro and age-related synaptic deficits ex vivo.

Product Specifications

CAS Number

1001389-31-6

Smiles

C (NCC1=C (Cl) C=C (Cl) C=C1) (=O) [C@H]2N (C) C (=O) CC2

Molecular Formula

C13H14Cl2N2O2

Molecular Weight

301.17

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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