AGN-190851

AGN-190851 is a selective alpha-2 adrenergic receptor agonist that functions as an aquaresis-inducing agent. It exerts its diuretic effect by suppressing vasopressin-mediated cAMP production within renal cortical collecting ducts, as demonstrated in murine models. This mechanism supports its research application in studying water balance disorders, renal physiology, and receptor-specific diuretic pathways.