CB-1158-analog
CB-1158-analog (INCB01158-analog) is a potent, orally bioavailable arginase inhibitor. It blocks myeloid-derived suppressor cell (MDSC) activity, enhancing anti-tumor immunity by increasing tumor-infiltrating CD8+ T and NK cells in vivo. This mechanism supports its research in cancer immunotherapy, including combinations with checkpoint inhibitors and chemotherapy in various cancer models.
Product Specifications
CAS Number
1345810-21-0
Field of Research
Immunology & Inflammation
Smiles
C (CCCCB (O) O) (C (O) =O) (N) C1CCN (CC2=C (Cl) C=C (Cl) C=C2) CC1
Molecular Formula
C18H27BCl2N2O4
Molecular Weight
417.14
Storage Conditions
-20°C
Notes
For research use only.
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