AZ5576 racemate
AZ5576 racemate is a potent, selective, and orally bioavailable CDK9 inhibitor with an enzyme IC50 <5 nM. It reduces RNAPII phosphorylation and Mcl1 expression, inducing apoptosis in MLL-fusion AML models like MV4;11 cells, supporting its use in oncology research for studying transcriptional dependencies in vitro.
Product Specifications
CAS Number
1333468-05-5
Field of Research
Cell Biology
Smiles
O (C) C1=C (C=2C=C (NC (=O) [C@@H]3C[C@H] (NC (C) =O) CCC3) N=CC2) C=CC (F) =C1
Molecular Formula
C21H24FN3O3
Molecular Weight
385.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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