Cipamfylline

Cipamfylline is a selective PDE-4 inhibitor and theophylline analog studied for treating atopic and irritant contact dermatitis. Clinical trials showed it was more effective than a vehicle but less potent than hydrocortisone-17-butyrate, with systemic exposure potentially limiting higher-dose development. It serves as a research tool for investigating PDE-4's role in skin inflammation models.