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Netarsudil free base

Netarsudil (AR-11324) is a potent ROCK inhibitor with Ki values of 1 nM for ROCK1/2. It increases aqueous humor outflow by disrupting actin cytoskeleton and countering TGF-β2 effects in trabecular meshwork cells. In vivo studies in animal models demonstrate its sustained IOP-lowering efficacy with once-daily dosing.

Product Specifications

CAS Number

1254032-66-0

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Smiles

N (C ([C@H] (CN) C1=CC=C (COC (=O) C2=C (C) C=C (C) C=C2) C=C1) =O) C3=CC4=C (C=C3) C=NC=C4

Molecular Formula

C28H27N3O3

Molecular Weight

453.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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