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Atiprimod (free base)

Atiprimod is an orally active azaspirane that inhibits STAT3 phosphorylation, disrupting IL-6 and VEGF signaling. This action downregulates anti-apoptotic proteins like Bcl-2, leading to cell cycle arrest and apoptosis in various cancer models, as demonstrated in both in vitro and in vivo studies.

Product Specifications

CAS Number

123018-47-3

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Smiles

C (CCN (CC) CC) N1CC2 (CCC (CCC) (CCC) CC2) CC1

Molecular Formula

C22H44N2

Molecular Weight

336.6

Storage Conditions

-20°C

Notes

For research use only.

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