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GNE-900

GNE-900 is a potent, selective, and orally bioavailable ATP-competitive inhibitor of ChK1 (IC50=1.1 nM) over ChK2. It enhances DNA damage-induced cell death and demonstrates antitumor activity in preclinical models, making it a valuable tool for studying DNA damage response and oncology research.

Product Specifications

CAS Number

1200126-26-6

Product Name Alternative

Chk1, Apoptosis, GNE 900, GNE900, GNE-900, Omeprazole acid

Field of Research

Cell Biology

Purity

97.18% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.72 mM) ; DMSO:3.85 mg/mL (10.48 mM)

Smiles

C (#N) C=1C=C2C=3C (NC2=CN1) =NC=C (C3) C4=CC=C (CN5CCCCC5) C=C4

Molecular Formula

C23H21N5

Molecular Weight

367.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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