GNF-8625
GNE-8525 is a potent and selective pan-TRK inhibitor, demonstrating in vitro antiproliferative activity and in vivo efficacy in xenograft models. It is a valuable research tool for studying TRK-driven oncogenesis in cancers such as colorectal, thyroid, and glioblastoma, where TRK fusions are key drivers.
Product Specifications
CAS Number
1196546-33-4
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
FC=1C=C ([C@@H]2N (C3=NN4C (=CN=C4C=C3) C=5N=C (C=CC5) C=6C=C (N=CC6) N7CCC (O) CC7) CCC2) C=CC1
Molecular Formula
C31H30FN7O
Molecular Weight
535.61
Storage Conditions
-20°C
Notes
For research use only.
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