BPR1K653

BPR1K653 is a potent and selective Aurora-A/B kinase inhibitor with broad-spectrum anticancer activity in vitro, overcoming MDR1-mediated resistance. It induces endoreplication and apoptosis in cancer cells and demonstrates significant in vivo efficacy in xenograft models, including MDR1-positive tumors, supported by favorable pharmacokinetic profiles. This makes it a promising candidate for oncology research, particularly in studying drug-resistant malignancies.