K-Ras G12C-IN-3
Product Specifications
UNSPSC Description
K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
IC50 value:
Target: K-ras G12C inhibitor
For more information, please see the following patent.
Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereof
By Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao
From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/K-Ras-G12C-IN-3.html
Purity
99.94
Solubility
DMSO : ≥ 30 mg/mL
Smiles
ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl
Molecular Weight
453.75
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18606/K-Ras-G12C-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18606/K-Ras-G12C-IN-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1629268-19-4
Available Sizes
Curated Selection
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