K-Ras G12C-IN-3

K-Ras G12C-IN-3 (Compound VI-5) is an irreversible small molecule inhibitor of mutant K-Ras G12C. K-Ras G12C-IN-3 can be used in the research of cancers[1].

Product Specifications

CAS Number

[1629268-19-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/K-Ras-G12C-IN-3.html

Purity

99.94

Solubility

DMSO : ≥ 30 mg/mL

Smiles

ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl

Molecular Formula

C21H19Cl3N2O3

Molecular Weight

453.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Ren, et al. Covalent inhibitors of K-Ras G12C. US9926267B2. United States. 2015-11-05.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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