K-Ras G12C-IN-3
K-Ras G12C-IN-3 (Compound VI-5) is an irreversible small molecule inhibitor of mutant K-Ras G12C. K-Ras G12C-IN-3 can be used in the research of cancers[1].
Product Specifications
CAS Number
[1629268-19-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/K-Ras-G12C-IN-3.html
Purity
99.94
Solubility
DMSO : ≥ 30 mg/mL
Smiles
ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl
Molecular Formula
C21H19Cl3N2O3
Molecular Weight
453.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Ren, et al. Covalent inhibitors of K-Ras G12C. US9926267B2. United States. 2015-11-05.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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