(S) - (-) -Bay-K-8644
(S) - (-) -Bay-K-8644 is an agonist of L-type Ca2+ channel. (S) - (-) -Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM) .
Product Specifications
CAS Number
98625-26-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Bay-K-8644-_S_-_-_-.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C([N+]([O-])=O)[C@@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1
Molecular Formula
C16H15F3N2O4
Molecular Weight
356.30
Precautions
H315, H319
References & Citations
[1]Zhu HL, et al. Antagonistic actions of S (-) -Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba (2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378 (6) :609-15.|[2]Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 (Pt 1) :75-87.|[3]Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S) -Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41 (4) :599-602.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC041081-100 1x 100 µL
CD45RO (190-2F2.5), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC550633-100 1x 100 µL
Von Willebrand Factor (3E2D10), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 