(S) - (-) -Bay-K-8644

(S) - (-) -Bay-K-8644 is an agonist of L-type Ca2+ channel. (S) - (-) -Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM) .

Product Specifications

CAS Number

[98625-26-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Bay-K-8644-_S_-_-_-.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C([N+]([O-])=O)[C@@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1

Molecular Formula

C16H15F3N2O4

Molecular Weight

356.30

Precautions

H315, H319

References & Citations

[1]Zhu HL, et al. Antagonistic actions of S (-) -Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba (2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378 (6) :609-15.|[2]Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 (Pt 1) :75-87.|[3]Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S) -Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41 (4) :599-602.