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NPE-caged-AppNHp

(NPE-caged-AMPPNP)

Product Specifications

CAS Number

116271-21-7

Product Name Alternative

(NPE-caged-AMPPNP), Adenosine-5'-[ (β, γ) -imido]triphosphate, P3- (1- (2-nitrophenyl) -ethyl) -ester, Triethylammonium salt

Concentration

10 mM-11 mM

Purity

≥ 95% (HPLC)

Form

Solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5

Smiles

[C@@H]1 ([C@H] ([C@@H] (O[C@@H]1COP (=O) (OP (=O) (NP (=O) (OC (c1ccccc1[N+] (=O) [O-]) C) O) O) O) n1c2c (nc1) c (ncn2) N) O) O

Molecular Formula

C18H24N7O14P3

Molecular Weight

Theoretical MW: 655.35 g/mol (free acid) ; Detected MW: 655.06 g/mol (free acid)

Storage Conditions

Store at -20 °C. store dark. Short term exposure (up to 1 week cumulative) to ambient temperature possible

Notes

For research use only.

Applications Notes

Agonistic ligand, mainly for nucleoside receptor A1 Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors. The caged form is protected during uptake and transport in animal experiments and can be well-directed released through activation at the target tissue. Spectroscopic Propertie: λmax 260 nm, ε 18.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5) .

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