Guanosine-3',5'-pentaphosphate
(p) ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria. During nutritional starvation (p) ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p) ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA) . Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival.
Product Specifications
Product Name Alternative
3',5'-pppGpp, Guanosine-3'-diphosphate-5'-triphosphate, Lithium salt
Concentration
100 mM-110 mM
Purity
≥ 85% (HPLC)
Form
Solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
Smiles
[nH]1c (N) nc2n ([C@H]3[C@H] (O) [C@@H] ([C@H] (O3) COP (=O) (O) OP (=O) (OP (=O) (O) O) O) OP (=O) (O) OP (=O) (O) O) cnc2c1=O
Molecular Formula
C10H18N5O20P5
Molecular Weight
Theoretical MW: 683.14 g/mol (free acid) ; Detected MW: 682.92 g/mol (free acid)
Storage Conditions
Store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible
Notes
For research use only.
Applications Notes
Spectroscopic Propertie: λmax 252 nm, ε 13.6 L mmol-1 cm-1 (Tris-HCl, pH 7.5) .
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