DW14800
DW14800 is a potent and selective PRMT5 inhibitor (IC50 = 17 nM) that reduces histone H4R3 symmetric dimethylation (H4R3me2s) and subsequently upregulates HNF4α transcription. This small molecule is a valuable chemical probe for investigating PRMT5 biology in epigenetic regulation, cancer research, and metabolic studies in both cellular and animal models.
Product Specifications
CAS Number
2243709-60-4
Product Name Alternative
Histone Methyltransferase, HistoneMethyltransferase, DW 14800, DW14800, DW-14800, PRMT5
Field of Research
Epigenetics & Chromatin
Purity
97.26% (May vary between batches)
Solubility
DMSO:45 mg/mL (87.78 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM)
Smiles
C (=O) (N1CC=2C (=CC (C (NCC (CN3CC=4C (CC3) =CC=CC4) O) =O) =CC2) CC1) C5=CC=C (N (C) C) C=C5
Molecular Formula
C31H36N4O3
Molecular Weight
512.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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