(5Z) -7-Oxo-Zeaenol
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible, and selective TAK1 inhibitor (IC50 = 8.1 nM) with additional activity against VEGF-R2 (IC50 = 52 nM) . It is widely used as a chemical probe in research to investigate TGF-β and NF-κB signaling pathways in both cellular and animal models of inflammation and cancer.
Product Specifications
CAS Number
253863-19-3
Product Name Alternative
LL-Z-1640-2
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
TAK1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 9 mg/ml) or in Ethanol (up to 3 mg/ml)
Smiles
COc1cc (O) c2c (c1) \C=C\C[C@H] (O) [C@H] (O) C (=O) \C=C/C[C@H] (C) OC2=O
Molecular Formula
C19H22O7
Molecular Weight
362.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(3S,5Z,8S,9S,11E) -3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7 (8H) -dione
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