ICG-001

ICG001 is a selective small molecule inhibitor that disrupts the β-catenin/CBP interaction to block Wnt/β-catenin signaling, with an IC50 of 3 μM for CREB binding. It is a valuable research tool for studying oncogenic signaling in cancers, including colorectal carcinoma, in both cellular and animal models.

Product Specifications

CAS Number

780757-88-2

Product Name Alternative

Inhibit, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, ICG 001, ICG001, ICG-001, betacatenin, beta-catenin, Beta catenin, CBP, 847591-62-2, bcatenin, Apoptosis, β-catenin, βcatenin, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

99.55% (May vary between batches)

Solubility

2% DMSO+40% PEG300+5% Tween 80+53% Saline:10 mg/mL (18.23 mM) ; DMSO:242 mg/mL (441.1 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:9 mg/mL (16.4 mM)